I B Genetic Polymorphisms and Invasive Pneumococcal Disease
نویسندگان
چکیده
The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford Radcliffe Hospital, Oxford, United Kingdom; Department of Respiratory Medicine, Royal Berkshire Hospital, Reading, United Kingdom; Department of Paediatrics, John Radcliffe Hospital, Oxford, United Kingdom; Centre for Medical Microbiology, Department of Infection, University College London, London, United Kingdom; Medical Research Council UK Mouse Genome Centre and Mammalian Genetics Unit, Harwell, Oxon, United Kingdom; Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Vietnam; and Department of Microbiology, John Radcliffe Hospital, Oxford, United Kingdom
منابع مشابه
Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study
INTRODUCTION Streptococcus pneumoniae remains a major global health problem and a leading cause of death in children worldwide. The factors that influence development of pneumococcal sepsis remain poorly understood, although increasing evidence points towards a role for genetic variation in the host's immune response. Recent insights from the study of animal models, rare human primary immunodef...
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Objective/purpose Genetic association studies have identified several polymorphisms in genes of the innate immunity cascade that appear to influence susceptibility to asthma and other inflammatory diseases. However, most candidate genes have not been functionally characterized for their impact on human immune responsiveness. An excellent candidate for functional investigation is NFKBIA which en...
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It has been suggested that genetic variants in mannose binding lectin (MBL2) influence susceptibility and outcome of invasive pneumococcal disease. We assessed the influence of genetic variation in MBL2 on susceptibility, outcome and causative serotype of pneumococcal meningitis in a prospective nationwide cohort study including 299 white patients and 216 controls. We assessed functionality of ...
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Previous studies of the association between the mannose-binding lectin pathway deficiencies and invasive pneumococcal disease are inconclusive. Invasiveness of Streptococcus pneumoniae is dependent on serotype. We aimed to determine the association between invasive pneumococcal disease and MBL2 and MASP2 genetic variants, regarding serotype distribution. A hospital-based case-control study was ...
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